The Detroit–Windsor region is an international transborder agglomeration named for the American city of Detroit, Michigan, the Canadian city of Windsor, Ontario, and the Detroit River, which separates them. The Detroit–Windsor area acts as a critical commercial link straddling the Canada–United States border and has a total population of 5,976,59…The Detroit–Windsor region is an international transborder agglomeration named for the American city of Detroit, Michigan, the Canadian city of Windsor, Ontario, and the Detroit River, which separates them. The Detroit–Windsor area acts as a critical commercial link straddling the Canada–United States border and has a total population of 5,976,595. It is North America's largest cross-border conurbation.