The San Francisco 49ers have had a strong start to the season despite major injury issues and that could have them looking to buy at the NFL trade deadline.

Defensive coordinator Robert Saleh believes that one particular rookie has the potential to earn veteran-like status with the 49ers. The 49ers drafted Collins in the second round, and that choice paid dividends in Week 4 against the Los Angeles Rams.

Quarterbacks Lamar Jackson and Kyler Murray did not practice for their respective teams on Thursday. Jackson is dealing with a hamstring issue that sidelined him during Baltimore's Week 5 loss to the Texans. Murray has been hampered by a foot injury that was sustained during the second half of Arizona's Week 5 loss against the Titans.

The San Francisco 49ers are off to a hot start this 2025 NFL season, going 4-1 through five weeks of pro football. However, it has also been a brutal run for them injury-wise, with several players missing games.

Also, the Eagles continue to struggle with offensive balance, and Baker Mayfield impresses again in Buccaneers' win.