In a recent study published in JAMA Network Open, researchers explored how structural and functional aspects of the brain, as seen through neuroimaging, differ between individuals with high exposure ...

Patients are commonly diagnosed with treatment-resistant depression when they do not improve despite receiving two or more pharmacologic treatments for an adequate dose and duration during the same ...

Treatment-resistant (refractory) depression has been a fertile topic for several decades (e.g., Freyhan, 1978; Nierenberg & Amsterdam, 1990; Voineskos, 2020). Unfortunately, as noted by Voineskos, ...

A new genetic and clinical analysis suggests that atypical depression represents a distinct biological subtype of the disorder with specific implications for treatment. The study found that ...