The glomerular filtration barrier comprises three interdependent layers: a fenestrated endothelium coated by a glycocalyx, a specialised glomerular basement membrane and podocyte foot processes linked ...

Human kidneys produce more than 4 million litres of virtually protein-free primary urine in a lifetime. In healthy individuals, the sieving process is accomplished by the glomerular filter without the ...

A team of scientists now reports an approach that enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency. Linking the ...

The inherited forms of proteinuria comprise a heterogeneous group of rare renal diseases in which glomerular dysfunction and proteinuria are prominent. Despite the rarity of hereditary proteinuria ...

The glomerulus has a critical function as the filtration barrier in the kidney. Podocytes, basement membrane, and endothelial cells function together to ensure the selective removal of metabolic waste ...