One of the simplest methods to disable USB ports in Windows 10 is through the Device Manager. Here’s how you can do it: Modify the Start Value: Double-click on the "Start" value and change the "Value ...
No, you'd just need to remove the HID class drivers, for example. So disallow HID_DEVICE, HID_DEVICE_SYSTEM_MOUSE and HID_DEVICE_SYSTEM_KEYBOARD. This would, if I'm following Coleman's link right, ...