San Francisco 49ers, The Cardinals
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Undefeated NFC West rivals square off in Week 3 NFL action as the San Francisco 49ers host the Arizona Cardinals. Kyler Murray and the Cardinals face their first division rival of the season after kicking off the 2025 campaign with wins against the New Orleans Saints and the Carolina Panthers.
Eddy Pineiro has kicked a 35-yard field goal to give the San Francisco 49ers a 16-15 win over the Arizona Cardinals.
USA TODAY Touchdown Wire on MSN
Will 49ers-Cardinals be on in my area? Week 3 broadcast map, TV channel
The San Francisco 49ers earned back-to-back road wins and will now be coming home in Week 3. Here's how to tell if the game will be on TV near you
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Where to watch Cardinals vs. 49ers: TV channel, live stream, prediction, pick, odds, spread
The Niners are without their starting quarterback, Brock Purdy, and have Mac Jones at the helm. He struggled with turning the ball over between his time with the New England Patriots and Jacksonville Jaguars, but put up 279 yards, three touchdowns and no picks last week.
Want to watch this showdown between Arizona and San Francisco? Here's everything you need to stream Sunday's 4:25 p.m. ET game on Fox.
The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.
The San Francisco 49ers looked at some quarterback options this week as they deal with injury issues for both Brock Purdy and Mac Jones.
Mac Jones is slated to start in place of the injured Brock Purdy on Sunday against the Bucs, while receiver Ricky Pearsall will miss his second straight game.
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Brock Purdy, Ricky Pearsall ruled out, Mac Jones questionable as 49ers injury nightmare continues
The 49ers are already without tight end George Kittle, who is on injured reserve with a hamstring injury, and wide receiver Brandon Aiyuk, who has yet to debut in 2025 after suffering tears to both his ACL and MCL in his right knee last October.
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