Retrosynthesis or retrosynthetic analysis (RA) is a strategic organic chemistry approach that scientists use to construct target molecules from easy-to-make or readily available precursors. 2 ...

Retrosynthesis aims to predict a set of reactants for producing given molecules, which plays a significant part in the biochemistry field, such as molecular pathway design and drug discovery. Most ...

Synthetic route design remains a major challenge in medicinal chemistry and small-molecule research, where chemists must balance feasibility, efficiency, scalability, and innovation while advancing ...

Synthetic route design remains a critical bottleneck in small‑molecule drug discovery, especially as teams juggle complex targets, aggressive timelines, and sustainability expectations.

Chemical engineers have trained a neural network model to plan synthetic routes to any target molecule, optimizing user-specified objectives such as cost, time, and sustainability. Researchers, from ...

Researchers at EPFL have developed 'Synthegy', a framework that uses large language models to guide retrosynthesis and reaction mechanism planning in chemistry. By interpreting natural-language ...

UPDATE - March 2016: On Friday the 11th of March 2016, Burlington House was the venue for the final of the 3rd National Retrosynthesis Competition. This event was jointly organised by the Heterocyclic ...