No. 9 Creighton (24-10) takes the court Thursday against No. 8 Louisville (27-7) in the first of four games in the First Round in the South Region. It is a matchup of teams who lost in their respective conference title games.

An opening-round NCAA Tournament matchup will see the ninth-seeded Creighton Bluejays (24-10) play against the No. 8 seed Louisville Cardinals (27-7) on Thursday at Rupp Arena. The contest begins

It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.