DFS millionaire Mike McClure shares his top daily Fantasy football picks for San Francisco 49ers vs. Detroit lions on MNF

This week’s Monday Night Football game features the Detroit Lions visiting the San Francisco 49ers. The Lions have been the #1 seed in the NFC for most of the season, but the Vikings finally caught up to them this week.

Week 17 of the NFL season concludes with the Detroit Lions taking on the San Francisco 49ers on Monday Night Football

Who is getting projected to the Lions with their first-round pick as we round up the mock drafts from Christmas week

ESPN's Football Power Index projects the 2025 NFL draft order for Round 1. Which teams have the best odds to pick early?

Game No. 272 on Sunday night between the Detroit Lions and Minnesota Vikings is a showdown for the NFC North and the conference’s top spot. The loser drops to the No. 5 seed. The Lions hold the tiebreaker in case the teams tie.

The Lions host the Vikings on "Sunday Night Football" to end the regular season, the first regular-season game in NFL history between teams with 13-plus wins. You couldn't draw up a regular-season game with much more at stake than this one.

Vikings at Lions on “Sunday Night Football.” The last game of the NFL regular season. Winner earns the NFC North title and gets the No. 1 seed, a first-round bye and home-field advantage in the playoffs.