Coach Dan Campbell stood at the podium after Detroit blew a 17-point lead to San Francisco in last season's NFC title game and talked about how that might have been the Lions only shot at reaching the Super Bowl.

The Detroit Lions will know how meaningful their matchup with the San Francisco 49ers on Monday night will carry before they step on the field. If Minnesota defeats Green Bay

The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's NFC Championship Game. Which five Lions players pose the biggest challenges to the 49ers' chances of victory?

To make matters worse, offensive lineman Spencer Burford, who was supposed to start at left tackle with Williams and his backup Jaylon Moore on IR for the season, is listed as ‘out’ on the injury report with a calf injury he sustained in the team’s Week 16 loss to the Miami Dolphins.

The bad injury situation exacerbated for the 49ers during the week with multiple downgrades – Colton McKivitz, Charvarius Ward, and Ji’Ayir Brown. Two of those are starting secondary players which would hamper the 49er pass defense. Meanwhile, the Lions got an upgrade with Terrion Arnold.

Spencer Burford officially has been ruled out of San Francisco's Week 17 game against the Detroit Lions on Monday night at Levi's Stadium.