No. 9 Creighton (24-10) takes the court Thursday against No. 8 Louisville (27-7) in the first of four games in the First Round in the South Region. It is a matchup of teams who lost in their respective conference title games.

Louisville was hurt by its seeding after a tough nonconference schedule, a second-place finish in the ACC and only two losses since Christmas. With Creighton looming, the Cardinals have already

It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.