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HCN Channels in Alzheimer’s and Parkinson’s Disease
HCN channels regulate neuronal excitability, rhythm, and plasticity. In Alzheimer’s disease, their dysfunction disrupts hippocampal signaling and memory, while in Parkinson’s disease, reduced Ih destabilizes dopaminergic pacemaking, accelerating degeneration. Though HCN modulation offers therapeutic promise, risks remain due to cardiac ...
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