Cascade impaction is the primary method for determination of the aerodynamic particle size distribution (APSD) of orally inhaled drug products (OIDPs), due to some unique qualities. A cascade impactor fractionates the particles into discrete size bands based on particle inertia and therefore accounts for how those particles behave in a moving air stream. This makes the technique intuitively relevant to particle deposition in the lungs. Furthermore cascade impaction allows the determination of ae
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