What is Charcot-Marie-Tooth disease (CMT)? Named after the three doctors who first described it in 1886: Charcot (shar-coh), Marie, and Tooth, Charcot-Marie-Tooth disease (CMT) is an inheritable peripheral neuropathy that includes many motor and/or sensory neuropathies, axonopathies, myelinopathies, and neuronopathies. Due to the degradation of their nerves, people with CMT suffer lifelong progressive muscle weakness and atrophy of the arms and legs, progressive sensory loss, and CMT can affect